First to be applied to hepatoblastoma, this technology could speed discovery and testing of new drugs for many forms of childhood and adult cancer.

We hypothesize that HAS2 and IL13RA2 turn DIPG cells into “stem-like” cells that grow quickly and invade into the cancer-promoting environment caused by HAS2.

The Plexin-Semaphorin pathway is previously unexplored as a target in sarcomas but may play a central role in the progression of the soft tissue sarcoma, rhabdomyosarcoma.

Already funded by the Trey Foote Foundation This project funds a childhood cancer research scientist to explore how resistance to chemotherapy and radiation can be

Already funded by the Alex’s Lemonade Stand Foundation Alveolar rhabdomyosarcoma is a cancer of the soft tissues. This disease often responds to chemotherapy, but in

Already funded by the National Cancer Institute (NIH) The major goal of this project is to test the hypothesis that IL4Rα blockade will prevent new

Already funded by a collective of partner family foundations! Soft tissue sarcomas are among the top 5 causes of death from childhood cancer.  Until now,

We propose to study anaplasia in Wilms’ tumor at a preclinical level to discover why anaplastic disease tends to be resistant to standard therapies and to predict a rational drug combination which might be more effective and less toxic for these children.

Already funded by Storm the Heavens Foundation in memory of Philomena Diffuse intrinsic pontine glioma (DIPG) is the greatest unmet need among childhood brain tumors,