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Our team of scientists and engineers are on a mission...

We are a nonprofit biotech lab on a mission to make childhood cancer universally survivable. Every year, the FDA approves on average 12 drugs to treat adult cancer, but has only approved 6 drugs to treat childhood cancer since 1978. We believe it’s time to do better. 

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Latest News

emma rens STEM

KPBS SU2C Emperor Science Award winner shares her experience working at cc-TDI

Emma Rens November 14, 2018

Hello! My name is Emma Rens, and I am a junior at the Academy of Our Lady of Peace High School in San Diego, California. Earlier this year, I wrote a blog post about the remarkable opportunity I was given through the KPBS Stand Up to Cancer Emperor Science Award to work with the Children’s Cancer Therapy Development Institute (cc-TDI) lab. Now that the program has finished, I am very excited to share my experience and research. When I first toured the lab in June, my mentor, Dr. Keller, shared with me the shocking statistic

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In the Press

Scientists And Parents Band Together To Research Cures For Rare Childhood Cancer

By Esther Landhuis - NPR
Small patient numbers mean there's less motivation to allocate resources to study the diseases and develop potential drugs. Dozens of childhood cancers fall in this category, some so rare that few pediatric oncologists hear about them.

Scientists Tackle Lethal Childhood Brain Cancer

By Esther Landhuis - Scientific American
In precision medicine era, legacy gifts of patient brain tissue reveal disease mechanisms and new therapeutic approaches.

Beaverton's Children's Cancer Therapy Development Institute tackles deadliest child cancers

By Eric Apalategui - Beaverton Valley Times
Beyond an unmarked door into what looks like a shabby old warehouse in Old Town Beaverton, white-coated scientists are working to find ways to treat cancers that kill almost every child they afflict.

Current Research Projects

The "Alexa" Project
The goal of The Alexa Project is to find new treatments to move towards clinical trials for all children affected with the neurofibromatosis-1 (NF1) associated brain tumors called juvenile pilocytic astrocytoma (JPA).
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Big Data Analytics of a massive drug screen by Cell of Origin
We have partnered with a major pharmaceutical company to conduct an unprecedented screen of more than 640,000 compounds that, when combined, could offer new treatments for pediatric cancers that haven’t seen progress in decades.
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The Functional Genomics of Wilms’ Tumor
Our Wilms’ tumor studies are led by Andy Woods, dad to Stellablue Woods, who was diagnosed with anaplastic Wilms’ tumor when she was just 4 years old. Andy brings the motivation of an impassioned father to our study, and is inspired by his personal experience with pediatric cancer to bring about better treatment options for children like his daughter.
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Epigenetic Therapy to Overcome Checkpoint Adaptation in Rhabdomyosarcoma
Our team has identified a cancer-causing gene (also known as an oncogene) called Pax3:Foxo1 that causes current treatments to fail. Remarkably, Pax3:Foxo1 can silenced by entinostat, a drug recently granted FDA breakthrough designation for breast cancer.
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Be a Dog’s Best Friend, Help a Child
To make it better for children & young adults with osteosarcoma, cc-TDI is exploring the types of non-chemotherapy drugs that re-program osteosarcoma tumor cells to stop growing – or cease to exist.
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Next Steps in the Rapid Preclinical Development of a Targeted Therapy Combination for Diffuse Intrinsic Pontine Glioma (DIPG)
Remarkably, this is the first time that a group of basic and translational scientists and physicians from institutions throughout North America and Europe have come together as a consortium to focus on a bench-to-bedside approach to rationally target therapy for children with DIPG.
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A dedicated research team

Our research team is exploring and testing state-of-the-art treatment options for the most urgent issues facing children with cancer. 

Working in our own freestanding research institution allows us to act swiftly and nimbly to achieve results—bringing cost control, speed, purpose, and focus to translate effective treatments into the clinic. To get there, we perform basic science and translational research in our industrial modern lab site (a paint factory remodeled by Nike as an off-site creative space), adjacent to the Silicon Forest in Oregon.

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EIN: 46-5759569

cc-TDI is a qualified 501(c)(3) charitable organization registered with the IRS
(consult with a CPA regarding specific tax implications)

 

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