Are you a PhD muscle, neuroscience or stem cell biologist interested to change paradigms and outcomes for childhood cancers?
cc-TDI offers a mentored research experience in a multidisciplinary setting of biologist and engineers, nestled in a facility minutes from the Portland-area medical center and Intel headquarters in the Silicon Forest. Your research project studying stem cell-like sarcomas or glial/neuronal brain tumors could fundamentally change the way we think about and approach rare cancer research.
Our approach has been to study childhood cancers (sarcomas, brain tumors and other high-mortality solid tumors) in the context of development and postnatal regenerative biology. We are widely collaborative with both universities and pharma. Highlights of our research program include the first demonstration that many translocation-mediated oncogenes are not expressed at a constant level, but are expressed in a cell-cycle phase-specific manner (G2 in the case of Pax3:Foxo1).
We have also established that tumor-initiating mutations such can be dispensable for tumor maintenance, but critically important for treatment resistance and tumor evolution through a process called checkpoint adaptation, which is borrowed by cancer cells from yeast. With respect to this type of paradigm shift, the cell-of-origin studies conducted by our laboratory have been the most informative in the development of potential new therapies. Specifically, our Nature Medicine, PLoS Genetics, Genes & Development and Science Signaling publications and our research have resulted in 3 national clinical trials for children with cancer in the last five years. Join us in making this impact through basic science and translational research!
Applicants can send their CV with contact information for 3 references to Dr. Charles Keller at firstname.lastname@example.org.